Hedgehog Signalling in Development Evolution and Disease
@ Biopolis, Singapore March 2012
Hedgehog (HH) proteins constitute one of a small number of families of secreted signals that play a central role in the development of metazoans. First discovered in Drosophila, research over the past 15 years has unveiled the key role played by HH signaling in human development and disease: aberrant HH signaling is now recognized as being associated with around 25% of all human cancers.
The HH research community has met at regular intervals over the last decade and the next meeting in this series will take place at Biopolis, Singapore in March, 2012.
As on previous occasions, the aim of this meeting is to bring together the leading researchers in the HH field to present their most recent findings and exchange ideas. The choice of Singapore as a venue reflects its growing presence on the world scientific stage, as well as the desire of the US/European HH community to engage more closely with the many HH researchers based in Asia and Oceania.
The meeting will reflect the many facets of HH signaling, with sessions devoted to the mechanisms of signal transduction, the developmental roles of HH, the evolutionary origins of the pathway, its involvement in human diseases and its importance as a therapeutic target, providing a well rounded and comprehensive survey of the field.
Organiser: Prof Philip INGHAM (Institute of Molecular and Cell Biology, A*STAR, Singapore)
Advisory Committee: Dr Xinhua LIN (Chinese Academy of Sciences, Beijing), Dr Mary Ann PRICE (Okinawa Institute of Science and Technology, Japan) and Dr Fred de SAUVAGE (Genentech, San Francisco, USA)